Drug interactions
Estradiol + Grapefruit
Severity: Minor
Estradiol and Grapefruit: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice can inhibit intestinal CYP3A4 and raise systemic exposure to oral estradiol. This may increase estrogen-related adverse effects, although the effect is generally modest.
What this interaction means in plain words
Estradiol and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Furanocoumarins in grapefruit inhibit intestinal CYP3A4, reducing first-pass metabolism of oral estradiol.
What to do
Advise patients to keep grapefruit intake consistent and to avoid large quantities with oral estradiol. Review for estrogenic adverse effects if intake changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Grapefruit?
MediHelp rates the interaction as minor. Estradiol and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice can inhibit intestinal CYP3A4 and raise systemic exposure to oral estradiol. This may increase estrogen-related adverse effects, although the effect is generally modest.
How serious is the interaction between Estradiol and Grapefruit?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to keep grapefruit intake consistent and to avoid large quantities with oral estradiol. Review for estrogenic adverse effects if intake changes.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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