Drug interactions
Estradiol + Griseofulvin
Severity: Moderate
Estradiol and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin can lower estradiol exposure and may reduce the effectiveness of estrogen therapy or contraceptives containing estrogen. Breakthrough bleeding, menstrual irregularity and contraceptive failure have been reported with griseofulvin.
What this interaction means in plain words
Estradiol and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estradiol belongs to Endocrine; Griseofulvin belongs to Anti Fungals.
Why it happens
Griseofulvin induces hepatic CYP3A4 and related enzymes, accelerating estradiol metabolism.
What to do
Monitor for loss of estrogen effect or breakthrough bleeding and consider dose adjustment. For contraception, advise an additional non-hormonal method during and for a period after griseofulvin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Griseofulvin?
MediHelp rates the interaction as moderate. Estradiol and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin can lower estradiol exposure and may reduce the effectiveness of estrogen therapy or contraceptives containing estrogen. Breakthrough bleeding, menstrual irregularity and contraceptive failure have been reported with griseofulvin.
How serious is the interaction between Estradiol and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of estrogen effect or breakthrough bleeding and consider dose adjustment. For contraception, advise an additional non-hormonal method during and for a period after griseofulvin therapy.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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