Drug interactions
Estradiol + Hydrocortisone
Severity: Minor
Estradiol and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens raise cortisol-binding globulin, increasing total cortisol while possibly reducing hydrocortisone clearance, so corticosteroid effect may be enhanced. This is mostly relevant in adrenal insufficiency on replacement therapy.
What this interaction means in plain words
Estradiol and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Hydrocortisone belongs to Endocrine.
Why it happens
Estradiol increases cortisol-binding globulin and may reduce corticosteroid clearance.
What to do
Monitor for signs of steroid excess or adjust hydrocortisone replacement dose when starting or stopping oral estrogen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Hydrocortisone?
MediHelp rates the interaction as minor. Estradiol and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens raise cortisol-binding globulin, increasing total cortisol while possibly reducing hydrocortisone clearance, so corticosteroid effect may be enhanced. This is mostly relevant in adrenal insufficiency on replacement therapy.
How serious is the interaction between Estradiol and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of steroid excess or adjust hydrocortisone replacement dose when starting or stopping oral estrogen.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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