Drug interactions
Estradiol + Indinavir
Severity: Moderate
Estradiol and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and P-glycoprotein and may raise estradiol exposure. This can increase estrogenic adverse effects such as breast tenderness, nausea and thromboembolic risk.
What this interaction means in plain words
Estradiol and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism and P-glycoprotein efflux increases estradiol levels.
What to do
Monitor for estrogen excess and titrate the estradiol dose to symptoms. Reduce the dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Indinavir?
MediHelp rates the interaction as moderate. Estradiol and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and P-glycoprotein and may raise estradiol exposure. This can increase estrogenic adverse effects such as breast tenderness, nausea and thromboembolic risk.
How serious is the interaction between Estradiol and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen excess and titrate the estradiol dose to symptoms. Reduce the dose if adverse effects appear.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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