Drug interactions
Estradiol + Lamotrigine
Severity: Moderate
Estradiol and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens can lower lamotrigine plasma concentrations, which may cause breakthrough seizures or loss of mood control. The effect has been best described with ethinylestradiol contraceptives, and is likely smaller with estradiol replacement.
What this interaction means in plain words
Estradiol and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estradiol belongs to Endocrine; Lamotrigine belongs to Central Nervous System.
Why it happens
Estrogen induction of UGT-mediated glucuronidation increases lamotrigine clearance.
What to do
Monitor seizure control and consider lamotrigine levels when estrogen is started, stopped or changed. Adjust the lamotrigine dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Lamotrigine?
MediHelp rates the interaction as moderate. Estradiol and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estrogens can lower lamotrigine plasma concentrations, which may cause breakthrough seizures or loss of mood control. The effect has been best described with ethinylestradiol contraceptives, and is likely smaller with estradiol replacement.
How serious is the interaction between Estradiol and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and consider lamotrigine levels when estrogen is started, stopped or changed. Adjust the lamotrigine dose as required.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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