Drug interactions
Estradiol + Lumefantrine
Severity: Minor
Estradiol and Lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is a weak CYP3A4 inducer in some data and could slightly lower estradiol exposure. Any effect is expected to be small and short-lived given the brief treatment course.
What this interaction means in plain words
Estradiol and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction increases estradiol metabolism.
What to do
No action is generally needed; consider noting any breakthrough bleeding or return of vasomotor symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Lumefantrine?
MediHelp rates the interaction as minor. Estradiol and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine is a weak CYP3A4 inducer in some data and could slightly lower estradiol exposure. Any effect is expected to be small and short-lived given the brief treatment course.
How serious is the interaction between Estradiol and Lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed; consider noting any breakthrough bleeding or return of vasomotor symptoms.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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