Drug interactions
Estradiol + Magnesium sulfate
Severity: Minor
Estradiol and Magnesium sulfate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may lower serum magnesium by promoting its uptake into tissues, but this has negligible relevance when magnesium sulfate is given therapeutically, for example in eclampsia.
What this interaction means in plain words
Estradiol and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Estrogen is proposed to shift magnesium from the blood into tissue stores.
What to do
No adjustment is needed; dose magnesium sulfate according to serum levels and clinical indication.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Magnesium sulfate?
MediHelp rates the interaction as minor. Estradiol and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may lower serum magnesium by promoting its uptake into tissues, but this has negligible relevance when magnesium sulfate is given therapeutically, for example in eclampsia.
How serious is the interaction between Estradiol and Magnesium sulfate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; dose magnesium sulfate according to serum levels and clinical indication.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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