Drug interactions
Estradiol + Meropenem / vaborbactam
Severity: Minor
Estradiol and Meropenem / vaborbactam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics were once thought to reduce estrogen recirculation by altering gut flora. Evidence of reduced efficacy of estradiol is lacking, and a carbapenem has no known enzyme-inducing effect.
What this interaction means in plain words
Estradiol and Meropenem / vaborbactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of enterohepatic recycling of estrogens through gut flora changes; not well established.
What to do
No action is needed for menopausal estradiol therapy. Counsel on backup contraception only if the estrogen is used for contraception.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Meropenem / vaborbactam?
MediHelp rates the interaction as minor. Estradiol and Meropenem / vaborbactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics were once thought to reduce estrogen recirculation by altering gut flora. Evidence of reduced efficacy of estradiol is lacking, and a carbapenem has no known enzyme-inducing effect.
How serious is the interaction between Estradiol and Meropenem / vaborbactam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for menopausal estradiol therapy. Counsel on backup contraception only if the estrogen is used for contraception.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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