Drug interactions
Estradiol vaginal + Fluconazole
Severity: Minor
Estradiol vaginal and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estradiol is partly metabolized by CYP3A4, so fluconazole could modestly raise estradiol levels. Systemic exposure from low-dose vaginal estradiol is small, so a clinically meaningful effect is unlikely.
What this interaction means in plain words
Estradiol vaginal and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Fluconazole inhibits CYP3A4, which may reduce estradiol metabolism.
What to do
No dose adjustment is needed; watch for estrogen excess effects such as breast tenderness or bleeding if systemic exposure is higher than expected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Estradiol vaginal with Fluconazole?
MediHelp rates the interaction as minor. Estradiol vaginal and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estradiol is partly metabolized by CYP3A4, so fluconazole could modestly raise estradiol levels. Systemic exposure from low-dose vaginal estradiol is small, so a clinically meaningful effect is unlikely.
How serious is the interaction between Estradiol vaginal and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; watch for estrogen excess effects such as breast tenderness or bleeding if systemic exposure is higher than expected.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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