Drug interactions
Estrogens, conjugated + Ketoconazole
Severity: Moderate
Estrogens, conjugated and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole is a strong CYP3A4 inhibitor and can increase estrogen concentrations. Higher exposure may cause estrogenic adverse effects and, with prolonged use, add to thromboembolic and endometrial risks.
What this interaction means in plain words
Estrogens, conjugated and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estrogens, conjugated belongs to Musculoskeletal; Ketoconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated estrogen metabolism.
What to do
Monitor for breast tenderness, bleeding and edema, and reduce the estrogen dose if adverse effects occur during prolonged ketoconazole use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Estrogens, conjugated and Ketoconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Estrogens, conjugated
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Estrogens, conjugated with Ketoconazole?
MediHelp rates the interaction as moderate. Estrogens, conjugated and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole is a strong CYP3A4 inhibitor and can increase estrogen concentrations. Higher exposure may cause estrogenic adverse effects and, with prolonged use, add to thromboembolic and endometrial risks.
How serious is the interaction between Estrogens, conjugated and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breast tenderness, bleeding and edema, and reduce the estrogen dose if adverse effects occur during prolonged ketoconazole use.
What other medicines interact with Estrogens, conjugated?
MediHelp also lists interactions of Estrogens, conjugated with, for example, Carbamazepine, Itraconazole, Phenobarbitone. The full list is on the Estrogens, conjugated page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
