Drug interactions
Clarithromycin + Estrogens, conjugated
Severity: Minor
Clarithromycin and Estrogens, conjugated: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin strongly inhibits CYP3A4 and may raise estrogen levels. This can cause estrogenic adverse effects such as breast tenderness, fluid retention or bleeding.
What this interaction means in plain words
Clarithromycin and Estrogens, conjugated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Estrogens, conjugated belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated estrogen metabolism.
What to do
Monitor for estrogenic adverse effects during the antibiotic course and lower the estrogen dose if they become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estrogens, conjugated
- Carbamazepine + Estrogens, conjugated Moderate
- Estrogens, conjugated + Itraconazole Moderate
- Estrogens, conjugated + Ketoconazole Moderate
- Estrogens, conjugated + Phenobarbitone Moderate
- Estrogens, conjugated + Rifampicin Moderate
- Estrogens, conjugated + Ritonavir Moderate
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Estrogens, conjugated?
MediHelp rates the interaction as minor. Clarithromycin and Estrogens, conjugated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin strongly inhibits CYP3A4 and may raise estrogen levels. This can cause estrogenic adverse effects such as breast tenderness, fluid retention or bleeding.
How serious is the interaction between Clarithromycin and Estrogens, conjugated?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects during the antibiotic course and lower the estrogen dose if they become troublesome.
What other medicines interact with Estrogens, conjugated?
MediHelp also lists interactions of Estrogens, conjugated with, for example, Carbamazepine, Itraconazole, Ketoconazole. The full list is on the Estrogens, conjugated page.
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