Drug interactions
Estrogens, conjugated + Itraconazole
Severity: Moderate
Estrogens, conjugated and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole strongly inhibits CYP3A4 and may increase estrogen exposure. Patients may experience more estrogenic adverse effects.
What this interaction means in plain words
Estrogens, conjugated and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estrogens, conjugated belongs to Musculoskeletal; Itraconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated estrogen metabolism.
What to do
Monitor for estrogenic adverse effects and reduce the estrogen dose if they develop, especially with prolonged antifungal courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estrogens, conjugated
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Estrogens, conjugated with Itraconazole?
MediHelp rates the interaction as moderate. Estrogens, conjugated and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole strongly inhibits CYP3A4 and may increase estrogen exposure. Patients may experience more estrogenic adverse effects.
How serious is the interaction between Estrogens, conjugated and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects and reduce the estrogen dose if they develop, especially with prolonged antifungal courses.
What other medicines interact with Estrogens, conjugated?
MediHelp also lists interactions of Estrogens, conjugated with, for example, Carbamazepine, Ketoconazole, Phenobarbitone. The full list is on the Estrogens, conjugated page.
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