Drug interactions
Estrogens, conjugated + Rifampicin
Severity: Moderate
Estrogens, conjugated and Rifampicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin is a potent inducer and can markedly reduce estrogen concentrations, leading to loss of symptom control and breakthrough bleeding.
What this interaction means in plain words
Estrogens, conjugated and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estrogens, conjugated belongs to Musculoskeletal; Rifampicin belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 and other metabolic enzymes increases estrogen clearance.
What to do
Monitor symptoms and bleeding and increase the estrogen dose if needed during rifampicin therapy. Reduce back after rifampicin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estrogens, conjugated
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Estrogens, conjugated with Rifampicin?
MediHelp rates the interaction as moderate. Estrogens, conjugated and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin is a potent inducer and can markedly reduce estrogen concentrations, leading to loss of symptom control and breakthrough bleeding.
How serious is the interaction between Estrogens, conjugated and Rifampicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptoms and bleeding and increase the estrogen dose if needed during rifampicin therapy. Reduce back after rifampicin is stopped.
What other medicines interact with Estrogens, conjugated?
MediHelp also lists interactions of Estrogens, conjugated with, for example, Carbamazepine, Itraconazole, Ketoconazole. The full list is on the Estrogens, conjugated page.
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