Drug interactions
Estrogens conjugated synthetic + Nevirapine
Severity: Moderate
Estrogens conjugated synthetic and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine can lower circulating estrogen exposure. This may reduce control of menopausal symptoms and the effectiveness of estrogen therapy.
What this interaction means in plain words
Estrogens conjugated synthetic and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nevirapine induces CYP3A4 and increases the metabolism of estrogens.
What to do
Monitor for loss of estrogen effect and titrate the estrogen dose to clinical response. Consider an alternative if symptoms are not controlled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Estrogens conjugated synthetic with Nevirapine?
MediHelp rates the interaction as moderate. Estrogens conjugated synthetic and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine can lower circulating estrogen exposure. This may reduce control of menopausal symptoms and the effectiveness of estrogen therapy.
How serious is the interaction between Estrogens conjugated synthetic and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of estrogen effect and titrate the estrogen dose to clinical response. Consider an alternative if symptoms are not controlled.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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