Drug interactions
Estrogens esterified + Fluconazole
Severity: Minor
Estrogens esterified and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase estrogen exposure by inhibiting CYP3A4. This may result in more estrogenic adverse effects such as breast tenderness and bleeding.
What this interaction means in plain words
Estrogens esterified and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated estrogen metabolism by fluconazole.
What to do
Monitor for estrogenic adverse effects during coadministration and adjust the estrogen dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Estrogens esterified with Fluconazole?
MediHelp rates the interaction as minor. Estrogens esterified and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole may increase estrogen exposure by inhibiting CYP3A4. This may result in more estrogenic adverse effects such as breast tenderness and bleeding.
How serious is the interaction between Estrogens esterified and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects during coadministration and adjust the estrogen dose if needed.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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