Drug interactions
Estrogens esterified + Nevirapine
Severity: Moderate
Estrogens esterified and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce exposure to esterified estrogens and weaken their therapeutic effect. Patients may experience recurrent menopausal symptoms or breakthrough bleeding.
What this interaction means in plain words
Estrogens esterified and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nevirapine induces CYP3A4 and accelerates estrogen metabolism.
What to do
Assess symptom control and bleeding pattern and increase the estrogen dose if needed, using the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Estrogens esterified with Nevirapine?
MediHelp rates the interaction as moderate. Estrogens esterified and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce exposure to esterified estrogens and weaken their therapeutic effect. Patients may experience recurrent menopausal symptoms or breakthrough bleeding.
How serious is the interaction between Estrogens esterified and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess symptom control and bleeding pattern and increase the estrogen dose if needed, using the lowest effective dose.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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