Drug interactions
Eszopiclone + Gabapentin enacarbil
Severity: Moderate
Eszopiclone and Gabapentin enacarbil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so using them together can deepen sedation, impair psychomotor performance and next-day alertness, and add to respiratory depression. The risk is greater in older adults, in people with lung disease, and at higher doses.
What this interaction means in plain words
Eszopiclone and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through pharmacodynamic synergy.
What to do
Use the lowest effective dose of each drug and counsel the patient about driving and operating machinery. Monitor for excessive sedation and respiratory depression, especially in patients with respiratory compromise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Eszopiclone with Gabapentin enacarbil?
MediHelp rates the interaction as moderate. Eszopiclone and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so using them together can deepen sedation, impair psychomotor performance and next-day alertness, and add to respiratory depression. The risk is greater in older adults, in people with lung disease, and at higher doses.
How serious is the interaction between Eszopiclone and Gabapentin enacarbil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of each drug and counsel the patient about driving and operating machinery. Monitor for excessive sedation and respiratory depression, especially in patients with respiratory compromise.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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