Drug interactions
Eszopiclone + Lenacapavir
Severity: Moderate
Eszopiclone and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor and may increase eszopiclone concentrations, with the effect persisting for months after subcutaneous dosing. This may cause greater sedation and next-day impairment.
What this interaction means in plain words
Eszopiclone and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Lenacapavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 metabolism of eszopiclone.
What to do
Use a reduced eszopiclone starting dose such as 1 mg and monitor for excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Eszopiclone with Lenacapavir?
MediHelp rates the interaction as moderate. Eszopiclone and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A4 inhibitor and may increase eszopiclone concentrations, with the effect persisting for months after subcutaneous dosing. This may cause greater sedation and next-day impairment.
How serious is the interaction between Eszopiclone and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced eszopiclone starting dose such as 1 mg and monitor for excess sedation.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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