Drug interactions
Eszopiclone + Methohexital
Severity: Moderate
Eszopiclone and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic, and combining it with eszopiclone can intensify sedation and respiratory depression.
What this interaction means in plain words
Eszopiclone and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive GABA-A mediated CNS depression.
What to do
Inform the anesthesia team of recent eszopiclone use and titrate methohexital carefully with continuous monitoring of respiration and oxygenation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Methohexital
Frequently asked questions
Can I take Eszopiclone with Methohexital?
MediHelp rates the interaction as moderate. Eszopiclone and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a barbiturate anesthetic, and combining it with eszopiclone can intensify sedation and respiratory depression.
How serious is the interaction between Eszopiclone and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of recent eszopiclone use and titrate methohexital carefully with continuous monitoring of respiration and oxygenation.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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