Drug interactions
Eszopiclone + Mifepristone
Severity: Moderate
Eszopiclone and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise eszopiclone concentrations. This can increase next-day sedation and psychomotor impairment.
What this interaction means in plain words
Eszopiclone and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4-mediated metabolism of eszopiclone, increasing exposure.
What to do
Limit the eszopiclone starting dose to the lowest level and monitor for daytime drowsiness, cognitive impairment and complex sleep behaviors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Eszopiclone with Mifepristone?
MediHelp rates the interaction as moderate. Eszopiclone and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise eszopiclone concentrations. This can increase next-day sedation and psychomotor impairment.
How serious is the interaction between Eszopiclone and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the eszopiclone starting dose to the lowest level and monitor for daytime drowsiness, cognitive impairment and complex sleep behaviors.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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