Drug interactions
Eszopiclone + Secobarbital
Severity: Major
Eszopiclone and Secobarbital: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital can reduce eszopiclone levels by inducing its metabolism, weakening the hypnotic effect. Both agents are CNS depressants, so concurrent use also raises risk of excess sedation and respiratory depression.
What this interaction means in plain words
Eszopiclone and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eszopiclone belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP3A4 accelerates eszopiclone clearance, combined with additive CNS depression.
What to do
Avoid concurrent use of two sedative-hypnotics; if unavoidable, monitor for both loss of efficacy and oversedation and counsel on impaired alertness.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eszopiclone
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Eszopiclone with Secobarbital?
MediHelp rates the interaction as major. Eszopiclone and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital can reduce eszopiclone levels by inducing its metabolism, weakening the hypnotic effect. Both agents are CNS depressants, so concurrent use also raises risk of excess sedation and respiratory depression.
How serious is the interaction between Eszopiclone and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two sedative-hypnotics; if unavoidable, monitor for both loss of efficacy and oversedation and counsel on impaired alertness.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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