Drug interactions
Eszopiclone + Voxelotor
Severity: Moderate
Eszopiclone and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can inhibit CYP3A4 and increase exposure to sensitive substrates, which may raise eszopiclone levels and sedation.
What this interaction means in plain words
Eszopiclone and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 by voxelotor reduces eszopiclone clearance.
What to do
Use the lowest eszopiclone dose (1 mg) and monitor for oversedation. Consider an alternative hypnotic if effects are excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Eszopiclone with Voxelotor?
MediHelp rates the interaction as moderate. Eszopiclone and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor can inhibit CYP3A4 and increase exposure to sensitive substrates, which may raise eszopiclone levels and sedation.
How serious is the interaction between Eszopiclone and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest eszopiclone dose (1 mg) and monitor for oversedation. Consider an alternative hypnotic if effects are excessive.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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