Drug interactions
Etanercept + Hepatitis a / typhoid vaccine
Severity: Minor
Etanercept and Hepatitis a / typhoid vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combined product is typically inactivated (Vi polysaccharide), so there is no risk of vaccine-strain infection. Etanercept may modestly reduce immune response. Vaccination is advisable before travel.
What this interaction means in plain words
Etanercept and Hepatitis a / typhoid vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
TNF blockade may mildly attenuate antibody production to non-live vaccines.
What to do
Give the injectable vaccine as indicated while continuing etanercept. Avoid the live oral typhoid vaccine in this patient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etanercept
- Bcg vaccine live + Etanercept Contraindicated
- Etanercept + Golimumab Contraindicated
- Etanercept + Measles mumps and rubella vaccine Contraindicated
- Etanercept + Measles mumps and rubella vaccine live Contraindicated
- Etanercept + Measles mumps rubella and varicella vaccine live Contraindicated
- Etanercept + Measles vaccine Contraindicated
Frequently asked questions
Can I take Etanercept with Hepatitis a / typhoid vaccine?
MediHelp rates the interaction as minor. Etanercept and Hepatitis a / typhoid vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The combined product is typically inactivated (Vi polysaccharide), so there is no risk of vaccine-strain infection. Etanercept may modestly reduce immune response. Vaccination is advisable before travel.
How serious is the interaction between Etanercept and Hepatitis a / typhoid vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the injectable vaccine as indicated while continuing etanercept. Avoid the live oral typhoid vaccine in this patient.
What other medicines interact with Etanercept?
MediHelp also lists interactions of Etanercept with, for example, Bcg vaccine live, Golimumab, Measles mumps and rubella vaccine. The full list is on the Etanercept page.
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