Drug interactions
Etanercept + Influenza virus vaccine quadrivalent
Severity: Minor
Etanercept and Influenza virus vaccine quadrivalent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The injectable inactivated influenza vaccine cannot cause influenza infection. Etanercept may slightly reduce the antibody response, but patients are still advised to be vaccinated each year because they are at higher risk of infection complications.
What this interaction means in plain words
Etanercept and Influenza virus vaccine quadrivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
TNF blockade may mildly decrease antibody responses to inactivated vaccine antigens.
What to do
Give the annual inactivated vaccine without interrupting etanercept. Do not use the live intranasal formulation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etanercept
- Bcg vaccine live + Etanercept Contraindicated
- Etanercept + Golimumab Contraindicated
- Etanercept + Measles mumps and rubella vaccine Contraindicated
- Etanercept + Measles mumps and rubella vaccine live Contraindicated
- Etanercept + Measles mumps rubella and varicella vaccine live Contraindicated
- Etanercept + Measles vaccine Contraindicated
Frequently asked questions
Can I take Etanercept with Influenza virus vaccine quadrivalent?
MediHelp rates the interaction as minor. Etanercept and Influenza virus vaccine quadrivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The injectable inactivated influenza vaccine cannot cause influenza infection. Etanercept may slightly reduce the antibody response, but patients are still advised to be vaccinated each year because they are at higher risk of infection complications.
How serious is the interaction between Etanercept and Influenza virus vaccine quadrivalent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the annual inactivated vaccine without interrupting etanercept. Do not use the live intranasal formulation.
What other medicines interact with Etanercept?
MediHelp also lists interactions of Etanercept with, for example, Bcg vaccine live, Golimumab, Measles mumps and rubella vaccine. The full list is on the Etanercept page.
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