Drug interactions
Etanercept + Muromonab cd3
Severity: Major
Etanercept and Muromonab cd3: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Muromonab-CD3 profoundly depletes T cells and, with etanercept, can markedly raise the risk of serious and opportunistic infection and lymphoproliferative disorders. The product is also no longer marketed.
What this interaction means in plain words
Etanercept and Muromonab cd3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression through T-cell depletion and TNF blockade.
What to do
Avoid the combination; if muromonab-CD3 is somehow used, hold etanercept and monitor closely for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Etanercept
- Bcg vaccine live + Etanercept Contraindicated
- Etanercept + Golimumab Contraindicated
- Etanercept + Measles mumps and rubella vaccine Contraindicated
- Etanercept + Measles mumps and rubella vaccine live Contraindicated
- Etanercept + Measles mumps rubella and varicella vaccine live Contraindicated
- Etanercept + Measles vaccine Contraindicated
Frequently asked questions
Can I take Etanercept with Muromonab cd3?
MediHelp rates the interaction as major. Etanercept and Muromonab cd3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Muromonab-CD3 profoundly depletes T cells and, with etanercept, can markedly raise the risk of serious and opportunistic infection and lymphoproliferative disorders. The product is also no longer marketed.
How serious is the interaction between Etanercept and Muromonab cd3?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if muromonab-CD3 is somehow used, hold etanercept and monitor closely for infection.
What other medicines interact with Etanercept?
MediHelp also lists interactions of Etanercept with, for example, Bcg vaccine live, Golimumab, Measles mumps and rubella vaccine. The full list is on the Etanercept page.
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