Drug interactions
Ethacrynic acid + Fludrocortisone
Severity: Moderate
Ethacrynic acid and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents increase urinary potassium loss, so combined use can cause marked hypokalemia. This raises the risk of arrhythmias and weakness, especially with digoxin or other QT-prolonging drugs.
What this interaction means in plain words
Ethacrynic acid and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Fludrocortisone belongs to Endocrine.
Why it happens
Additive kaliuresis from mineralocorticoid effect and loop diuretic-induced distal sodium delivery.
What to do
Monitor serum potassium and magnesium, and give potassium supplementation or adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Fludrocortisone?
MediHelp rates the interaction as moderate. Ethacrynic acid and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents increase urinary potassium loss, so combined use can cause marked hypokalemia. This raises the risk of arrhythmias and weakness, especially with digoxin or other QT-prolonging drugs.
How serious is the interaction between Ethacrynic acid and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, and give potassium supplementation or adjust doses as needed.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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