Drug interactions
Ethacrynic acid + Fluticasone-salmeterol
Severity: Moderate
Ethacrynic acid and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a loop diuretic that causes potassium loss, and salmeterol can further lower serum potassium. Together they may produce clinically significant hypokalemia, which increases arrhythmia risk, particularly in patients with heart disease or on digoxin.
What this interaction means in plain words
Ethacrynic acid and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive hypokalemia from renal potassium wasting (loop diuretic) and beta2-mediated cellular potassium uptake.
What to do
Monitor serum potassium and magnesium and replace as needed. Take extra care in patients with COPD exacerbations, hypoxia or cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Ethacrynic acid and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a loop diuretic that causes potassium loss, and salmeterol can further lower serum potassium. Together they may produce clinically significant hypokalemia, which increases arrhythmia risk, particularly in patients with heart disease or on digoxin.
How serious is the interaction between Ethacrynic acid and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and replace as needed. Take extra care in patients with COPD exacerbations, hypoxia or cardiac disease.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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