Drug interactions
Ethacrynic acid + Fosinopril
Severity: Moderate
Ethacrynic acid and Fosinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as ethacrynic acid cause volume depletion; adding fosinopril can produce marked first-dose hypotension and acute renal impairment. Risk is highest with high diuretic doses or low sodium intake.
What this interaction means in plain words
Ethacrynic acid and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Fosinopril belongs to Cardiovascular.
Why it happens
Diuretic-induced volume depletion combined with ACE inhibitor loss of angiotensin II-mediated efferent arteriolar tone.
What to do
Consider temporarily reducing or holding the diuretic before starting fosinopril and start at a low dose. Monitor blood pressure, creatinine and potassium in the first weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Fosinopril?
MediHelp rates the interaction as moderate. Ethacrynic acid and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as ethacrynic acid cause volume depletion; adding fosinopril can produce marked first-dose hypotension and acute renal impairment. Risk is highest with high diuretic doses or low sodium intake.
How serious is the interaction between Ethacrynic acid and Fosinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider temporarily reducing or holding the diuretic before starting fosinopril and start at a low dose. Monitor blood pressure, creatinine and potassium in the first weeks.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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