Drug interactions
Ethacrynic acid + Hydrochlorothiazide-telmisartan
Severity: Moderate
Ethacrynic acid and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a loop diuretic with a thiazide produces strong sequential nephron blockade. This can cause marked diuresis, volume depletion, hypokalemia, hyponatremia, hypotension and renal impairment. Ethacrynic acid also adds ototoxicity risk at high doses.
What this interaction means in plain words
Ethacrynic acid and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Additive diuresis from blockade of the loop Na-K-2Cl cotransporter and the distal sodium-chloride cotransporter.
What to do
Monitor electrolytes, renal function, weight and blood pressure, and reduce diuretic doses if volume depletion occurs. Replace potassium and magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Ethacrynic acid and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a loop diuretic with a thiazide produces strong sequential nephron blockade. This can cause marked diuresis, volume depletion, hypokalemia, hyponatremia, hypotension and renal impairment. Ethacrynic acid also adds ototoxicity risk at high doses.
How serious is the interaction between Ethacrynic acid and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure, and reduce diuretic doses if volume depletion occurs. Replace potassium and magnesium as needed.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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