Drug interactions
Ethacrynic acid + Hydrochlorothiazide-valsartan
Severity: Moderate
Ethacrynic acid and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a loop diuretic with hydrochlorothiazide and valsartan produces strong diuresis with a risk of hypokalemia, hyponatremia, volume depletion, hypotension and acute kidney injury. Ethacrynic acid also carries a risk of ototoxicity, especially at high doses or with renal impairment.
What this interaction means in plain words
Ethacrynic acid and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Sequential nephron blockade by loop and thiazide diuretics gives additive natriuresis and potassium loss, with ARB-related reduction in glomerular filtration pressure.
What to do
Monitor electrolytes, renal function, weight and blood pressure, particularly after starting or increasing doses. Adjust diuretic doses and replace potassium or magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Ethacrynic acid and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a loop diuretic with hydrochlorothiazide and valsartan produces strong diuresis with a risk of hypokalemia, hyponatremia, volume depletion, hypotension and acute kidney injury. Ethacrynic acid also carries a risk of ototoxicity, especially at high doses or with renal impairment.
How serious is the interaction between Ethacrynic acid and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure, particularly after starting or increasing doses. Adjust diuretic doses and replace potassium or magnesium as needed.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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