Drug interactions
Ethacrynic acid + Ibuprofen
Severity: Moderate
Ethacrynic acid and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can reduce the diuretic and natriuretic effect of loop diuretics such as ethacrynic acid. The combination also raises the risk of acute kidney injury, particularly with volume depletion.
What this interaction means in plain words
Ethacrynic acid and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
Ibuprofen inhibits renal prostaglandin synthesis, causing sodium and water retention and reducing renal perfusion.
What to do
Monitor urine output, weight, blood pressure and renal function, and increase diuretic dose if needed. Limit NSAID use to the lowest dose and shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Ibuprofen?
MediHelp rates the interaction as moderate. Ethacrynic acid and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen can reduce the diuretic and natriuretic effect of loop diuretics such as ethacrynic acid. The combination also raises the risk of acute kidney injury, particularly with volume depletion.
How serious is the interaction between Ethacrynic acid and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urine output, weight, blood pressure and renal function, and increase diuretic dose if needed. Limit NSAID use to the lowest dose and shortest duration.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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