Drug interactions
Ethacrynic acid + Lisinopril
Severity: Moderate
Ethacrynic acid and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretic-induced volume depletion combined with ACE inhibition can cause marked first-dose hypotension and acute renal impairment. The risk is highest in sodium- or volume-depleted patients and at initiation.
What this interaction means in plain words
Ethacrynic acid and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Lisinopril belongs to Cardiovascular.
Why it happens
Diuretic volume depletion activates the renin-angiotensin system, and ACE inhibition removes this compensation, causing hypotension and reduced glomerular filtration.
What to do
Consider lowering or temporarily holding the diuretic before starting lisinopril, and start with a low dose. Check blood pressure, creatinine and potassium within the first weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Lisinopril?
MediHelp rates the interaction as moderate. Ethacrynic acid and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretic-induced volume depletion combined with ACE inhibition can cause marked first-dose hypotension and acute renal impairment. The risk is highest in sodium- or volume-depleted patients and at initiation.
How serious is the interaction between Ethacrynic acid and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering or temporarily holding the diuretic before starting lisinopril, and start with a low dose. Check blood pressure, creatinine and potassium within the first weeks.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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