Drug interactions
Ethacrynic acid + Meclofenamic acid
Severity: Moderate
Ethacrynic acid and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamic acid can blunt the diuretic and natriuretic response to loop diuretics through reduced renal prostaglandin synthesis. The combination can also raise the risk of acute kidney injury, particularly in volume-depleted patients, and may cause fluid retention.
What this interaction means in plain words
Ethacrynic acid and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, antagonizing loop diuretic effect.
What to do
Monitor blood pressure, weight, fluid status and serum creatinine and electrolytes. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethacrynic acid and Meclofenamic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Meclofenamic acid?
MediHelp rates the interaction as moderate. Ethacrynic acid and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamic acid can blunt the diuretic and natriuretic response to loop diuretics through reduced renal prostaglandin synthesis. The combination can also raise the risk of acute kidney injury, particularly in volume-depleted patients, and may cause fluid retention.
How serious is the interaction between Ethacrynic acid and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight, fluid status and serum creatinine and electrolytes. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
