Drug interactions
Ethacrynic acid + Moexipril
Severity: Moderate
Ethacrynic acid and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as ethacrynic acid can cause volume depletion, and adding an ACE inhibitor may produce marked first-dose hypotension and acute renal impairment. Risk is greatest in patients who are sodium or volume depleted.
What this interaction means in plain words
Ethacrynic acid and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Moexipril belongs to Cardiovascular.
Why it happens
Diuretic-induced volume depletion combined with ACE inhibitor reduction of angiotensin II-mediated efferent arteriolar tone causes additive hypotension and reduced glomerular filtration.
What to do
Consider reducing or temporarily withholding the diuretic before starting the ACE inhibitor, begin with a low dose, and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Moexipril?
MediHelp rates the interaction as moderate. Ethacrynic acid and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as ethacrynic acid can cause volume depletion, and adding an ACE inhibitor may produce marked first-dose hypotension and acute renal impairment. Risk is greatest in patients who are sodium or volume depleted.
How serious is the interaction between Ethacrynic acid and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing or temporarily withholding the diuretic before starting the ACE inhibitor, begin with a low dose, and monitor blood pressure, creatinine and potassium.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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