Drug interactions
Ethacrynic acid + Sacubitril-valsartan
Severity: Moderate
Ethacrynic acid and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a loop diuretic that lowers potassium, whereas valsartan tends to raise it, so potassium changes may offset each other. The combination is common in heart failure, but diuretic-induced volume depletion can increase the risk of hypotension and renal impairment with sacubitril-valsartan.
What this interaction means in plain words
Ethacrynic acid and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Opposing potassium effects plus additive hypotensive and volume-depleting effects.
What to do
Monitor blood pressure, renal function and electrolytes after initiation or dose changes. Reduce the diuretic dose if symptomatic hypotension occurs with volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Ethacrynic acid and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a loop diuretic that lowers potassium, whereas valsartan tends to raise it, so potassium changes may offset each other. The combination is common in heart failure, but diuretic-induced volume depletion can increase the risk of hypotension and renal impairment with sacubitril-valsartan.
How serious is the interaction between Ethacrynic acid and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after initiation or dose changes. Reduce the diuretic dose if symptomatic hypotension occurs with volume depletion.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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