Drug interactions
Ethacrynic acid + Spironolactone
Severity: Minor
Ethacrynic acid and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid, a loop diuretic, causes potassium loss while spironolactone retains it, so potassium effects offset each other. Combined diuresis can cause volume depletion, hyponatremia and renal function changes.
What this interaction means in plain words
Ethacrynic acid and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethacrynic acid belongs to Cardiovascular; Spironolactone belongs to Cardiovascular.
Why it happens
Opposing renal potassium handling with additive natriuresis at different nephron sites.
What to do
Monitor serum electrolytes, renal function and volume status, adjusting doses accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Spironolactone?
MediHelp rates the interaction as minor. Ethacrynic acid and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethacrynic acid, a loop diuretic, causes potassium loss while spironolactone retains it, so potassium effects offset each other. Combined diuresis can cause volume depletion, hyponatremia and renal function changes.
How serious is the interaction between Ethacrynic acid and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum electrolytes, renal function and volume status, adjusting doses accordingly.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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