Drug interactions
Ethacrynic acid + Streptomycin
Severity: Major
Ethacrynic acid and Streptomycin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can damage the inner ear, and ethacrynic acid is especially associated with ototoxicity, sometimes irreversible. Combining them increases the risk of hearing loss and renal toxicity, particularly with renal impairment.
What this interaction means in plain words
Ethacrynic acid and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethacrynic acid belongs to Cardiovascular; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive cochlear and vestibular toxicity, with loop diuretic volume depletion also increasing aminoglycoside nephrotoxicity.
What to do
Avoid the combination if possible and use an alternative diuretic. If needed, monitor renal function, hydration, drug levels and audiometry.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Streptomycin
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Streptomycin?
MediHelp rates the interaction as major. Ethacrynic acid and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can damage the inner ear, and ethacrynic acid is especially associated with ototoxicity, sometimes irreversible. Combining them increases the risk of hearing loss and renal toxicity, particularly with renal impairment.
How serious is the interaction between Ethacrynic acid and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use an alternative diuretic. If needed, monitor renal function, hydration, drug levels and audiometry.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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