Drug interactions
Ethacrynic acid + Tobramycin
Severity: Major
Ethacrynic acid and Tobramycin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are ototoxic, and combined use raises the risk of permanent hearing loss and vestibular damage. Volume depletion and renal effects may increase tobramycin exposure.
What this interaction means in plain words
Ethacrynic acid and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethacrynic acid belongs to Cardiovascular; Tobramycin belongs to Anti Bacterial.
Why it happens
Additive ototoxicity and nephrotoxicity.
What to do
Avoid the combination if possible. If both are required, monitor audiometry, renal function and tobramycin levels, and maintain hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Tobramycin?
MediHelp rates the interaction as major. Ethacrynic acid and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are ototoxic, and combined use raises the risk of permanent hearing loss and vestibular damage. Volume depletion and renal effects may increase tobramycin exposure.
How serious is the interaction between Ethacrynic acid and Tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If both are required, monitor audiometry, renal function and tobramycin levels, and maintain hydration.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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