Drug interactions
Ethacrynic acid + Trandolapril
Severity: Moderate
Ethacrynic acid and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic, and with an ACE inhibitor it can cause marked hypotension, particularly after the first dose in volume-depleted patients. It can also cause acute deterioration of renal function.
What this interaction means in plain words
Ethacrynic acid and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Trandolapril belongs to Cardiovascular.
Why it happens
Diuretic-induced volume and sodium depletion activates the renin-angiotensin system, and ACE inhibition removes this compensation, causing hypotension and a fall in glomerular filtration.
What to do
Consider reducing or temporarily holding the diuretic before starting trandolapril and start with a low dose. Monitor blood pressure, renal function and electrolytes in the first weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Trandolapril?
MediHelp rates the interaction as moderate. Ethacrynic acid and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a potent loop diuretic, and with an ACE inhibitor it can cause marked hypotension, particularly after the first dose in volume-depleted patients. It can also cause acute deterioration of renal function.
How serious is the interaction between Ethacrynic acid and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing or temporarily holding the diuretic before starting trandolapril and start with a low dose. Monitor blood pressure, renal function and electrolytes in the first weeks.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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