Drug interactions
ethanol (alcohol) + pregabalin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive CNS depressant effects may increase dizziness, sedation, impaired psychomotor function, and risk of respiratory depression; heightened risk in elderly or patients with respiratory disease.
Mechanism of action
Pharmacodynamic: combined CNS depressant effects (sedation and respiratory drive suppression).
Clinical management
Advise avoidance of alcohol during pregabalin therapy. If not avoidable, limit intake, use the lowest effective pregabalin dose, and monitor for excessive sedation, confusion, and respiratory depression; avoid driving or hazardous tasks.
Drug reference
References
- Lyrica (pregabalin) Prescribing Information — FDA Label
- FDA warns about serious breathing problems with gabapentin and pregabalin (2019) — FDA Drug Safety Communication
- Pregabalin: Drug Information — Lexicomp
Frequently asked questions
Can I take ethanol (alcohol) with pregabalin?
The interaction is rated: Moderate. Additive CNS depressant effects may increase dizziness, sedation, impaired psychomotor function, and risk of respiratory depression; heightened risk in elderly or patients with respiratory disease.
How serious is the interaction between ethanol (alcohol) and pregabalin?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between ethanol (alcohol) and pregabalin managed?
Advise avoidance of alcohol during pregabalin therapy. If not avoidable, limit intake, use the lowest effective pregabalin dose, and monitor for excessive sedation, confusion, and respiratory depression; avoid driving or hazardous tasks.
Why do ethanol (alcohol) and pregabalin interact?
Pharmacodynamic: combined CNS depressant effects (sedation and respiratory drive suppression).
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