Drug interactions
Ethanol + Pregabalin
Severity: Moderate
Ethanol and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alcohol potentiates the sedative and psychomotor effects of pregabalin, leading to impaired thinking, coordination and alertness. Heavy intake with pregabalin may also increase the risk of respiratory depression.
What this interaction means in plain words
Ethanol and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through pharmacodynamic synergism.
What to do
Advise patients to avoid alcohol while taking pregabalin. Counsel about driving and hazardous tasks if alcohol is consumed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Frequently asked questions
Can I take Ethanol with Pregabalin?
MediHelp rates the interaction as moderate. Ethanol and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alcohol potentiates the sedative and psychomotor effects of pregabalin, leading to impaired thinking, coordination and alertness. Heavy intake with pregabalin may also increase the risk of respiratory depression.
How serious is the interaction between Ethanol and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid alcohol while taking pregabalin. Counsel about driving and hazardous tasks if alcohol is consumed.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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