Drug interactions
Ether + Midodrine
Severity: Major
Ether and Midodrine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ether is a historical anesthetic that sensitizes the myocardium to catecholamines. With sympathomimetics such as midodrine, ventricular arrhythmias and hypertension are possible.
What this interaction means in plain words
Ether and Midodrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Myocardial sensitization to catecholamines combined with alpha-agonist vasoconstriction.
What to do
Avoid midodrine around anesthesia with ether; hold it perioperatively. If unavoidable, use continuous ECG and blood pressure monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Ether with Midodrine?
MediHelp rates the interaction as major. Ether and Midodrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ether is a historical anesthetic that sensitizes the myocardium to catecholamines. With sympathomimetics such as midodrine, ventricular arrhythmias and hypertension are possible.
How serious is the interaction between Ether and Midodrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid midodrine around anesthesia with ether; hold it perioperatively. If unavoidable, use continuous ECG and blood pressure monitoring.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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