Drug interactions
Ethinyl estradiol-drospirenone + Istradefylline
Severity: Minor
Ethinyl estradiol-drospirenone and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At the higher 40 mg daily dose, istradefylline weakly inhibits CYP3A4 and can raise exposure to CYP3A4 substrates such as ethinyl estradiol. The rise is expected to be modest and may bring more estrogenic adverse effects.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Istradefylline belongs to Central Nervous System.
Why it happens
Dose-dependent inhibition of CYP3A4 by istradefylline reduces ethinyl estradiol metabolism.
What to do
No dose change is typically required; monitor for estrogenic adverse effects such as nausea, breast tenderness or hypertension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Istradefylline?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At the higher 40 mg daily dose, istradefylline weakly inhibits CYP3A4 and can raise exposure to CYP3A4 substrates such as ethinyl estradiol. The rise is expected to be modest and may bring more estrogenic adverse effects.
How serious is the interaction between Ethinyl estradiol-drospirenone and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is typically required; monitor for estrogenic adverse effects such as nausea, breast tenderness or hypertension.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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