Drug interactions
Ethinyl estradiol-drospirenone + Moexipril
Severity: Moderate
Ethinyl estradiol-drospirenone and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid, potassium-sparing activity, and ACE inhibitors reduce aldosterone secretion. Together they can raise serum potassium, which in susceptible patients such as those with renal impairment or diabetes may cause hyperkalemia.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Moexipril belongs to Cardiovascular.
Why it happens
Additive potassium retention from drospirenone's aldosterone antagonism and ACE inhibitor suppression of aldosterone.
What to do
Check serum potassium during the first cycle of combined use and periodically thereafter, especially with renal impairment; consider a different contraceptive if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Moexipril?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid, potassium-sparing activity, and ACE inhibitors reduce aldosterone secretion. Together they can raise serum potassium, which in susceptible patients such as those with renal impairment or diabetes may cause hyperkalemia.
How serious is the interaction between Ethinyl estradiol-drospirenone and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of combined use and periodically thereafter, especially with renal impairment; consider a different contraceptive if potassium rises.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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