Drug interactions
Ethinyl estradiol-drospirenone + Naproxen
Severity: Moderate
Ethinyl estradiol-drospirenone and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen can reduce renal potassium excretion and renal function, and drospirenone adds anti-mineralocorticoid effects. Hyperkalemia may occur with chronic use or kidney impairment.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Naproxen belongs to Musculoskeletal.
Why it happens
Additive potassium retention from NSAID suppression of renal prostaglandins and drospirenone aldosterone antagonism.
What to do
Check serum potassium in the first cycle with regular naproxen use. Occasional short-term use generally needs no monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Naproxen?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen can reduce renal potassium excretion and renal function, and drospirenone adds anti-mineralocorticoid effects. Hyperkalemia may occur with chronic use or kidney impairment.
How serious is the interaction between Ethinyl estradiol-drospirenone and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in the first cycle with regular naproxen use. Occasional short-term use generally needs no monitoring.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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