Drug interactions
Ethinyl estradiol-drospirenone + Nilotinib
Severity: Moderate
Ethinyl estradiol-drospirenone and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a CYP3A4 substrate that prolongs the QT interval, and ethinyl estradiol may weakly inhibit CYP3A4. Any rise in nilotinib exposure could increase QT risk, though the effect is expected to be small.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by ethinyl estradiol may raise nilotinib concentrations.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes during combined use; maintain normal potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Nilotinib?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib is a CYP3A4 substrate that prolongs the QT interval, and ethinyl estradiol may weakly inhibit CYP3A4. Any rise in nilotinib exposure could increase QT risk, though the effect is expected to be small.
How serious is the interaction between Ethinyl estradiol-drospirenone and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes during combined use; maintain normal potassium and magnesium.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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