Drug interactions
Ethinyl estradiol-drospirenone + Pitolisant
Severity: Moderate
Ethinyl estradiol-drospirenone and Pitolisant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant may induce CYP3A4 and can reduce the exposure of hormonal contraceptives, potentially lowering contraceptive efficacy. This effect persists for some time after pitolisant is stopped.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Pitolisant belongs to Central Nervous System.
Why it happens
Pitolisant is a weak CYP3A4 inducer that may increase metabolism of ethinyl estradiol and drospirenone.
What to do
Advise an additional non-hormonal contraceptive method during pitolisant treatment and for at least 21 days after stopping it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Pitolisant?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant may induce CYP3A4 and can reduce the exposure of hormonal contraceptives, potentially lowering contraceptive efficacy. This effect persists for some time after pitolisant is stopped.
How serious is the interaction between Ethinyl estradiol-drospirenone and Pitolisant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during pitolisant treatment and for at least 21 days after stopping it.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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