Drug interactions
Ethinyl estradiol-drospirenone + Potassium chloride
Severity: Moderate
Ethinyl estradiol-drospirenone and Potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone can increase serum potassium, and potassium chloride adds to the potassium load. Hyperkalemia may result, particularly in patients with renal impairment or on other potassium-raising drugs.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Potassium chloride belongs to Gastrointestinal Tract.
Why it happens
Additive hyperkalemia from drospirenone's antimineralocorticoid effect and exogenous potassium.
What to do
Measure serum potassium during the first treatment cycle and periodically afterward. Choose a different contraceptive if renal impairment or other risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Potassium chloride
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Potassium chloride?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone can increase serum potassium, and potassium chloride adds to the potassium load. Hyperkalemia may result, particularly in patients with renal impairment or on other potassium-raising drugs.
How serious is the interaction between Ethinyl estradiol-drospirenone and Potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum potassium during the first treatment cycle and periodically afterward. Choose a different contraceptive if renal impairment or other risk factors are present.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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