Drug interactions
Ethinyl estradiol-drospirenone + Propranolol
Severity: Minor
Ethinyl estradiol-drospirenone and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-selective beta-blockers such as propranolol can modestly raise serum potassium, and drospirenone adds potassium retention. The combined effect is usually small but may matter in renal impairment.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Propranolol belongs to Cardiovascular.
Why it happens
Mild additive effect: beta-blockade impairs cellular potassium uptake while drospirenone reduces renal excretion.
What to do
No routine change; check potassium if renal impairment or other potassium-raising drugs are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Propranolol?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-selective beta-blockers such as propranolol can modestly raise serum potassium, and drospirenone adds potassium retention. The combined effect is usually small but may matter in renal impairment.
How serious is the interaction between Ethinyl estradiol-drospirenone and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change; check potassium if renal impairment or other potassium-raising drugs are present.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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