Drug interactions
Ethinyl estradiol-drospirenone + Rasagiline
Severity: Minor
Ethinyl estradiol-drospirenone and Rasagiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is cleared mainly by CYP1A2, and ethinyl estradiol inhibits this enzyme weakly. Rasagiline exposure may rise, increasing its adverse effects.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Rasagiline belongs to Central Nervous System.
Why it happens
Weak CYP1A2 inhibition by ethinyl estradiol reducing rasagiline clearance.
What to do
Monitor for increased rasagiline effects such as dizziness, hypotension and dyskinesia, and keep the dose at 0.5 mg daily if CYP1A2 inhibition is clinically relevant.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Rasagiline?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rasagiline is cleared mainly by CYP1A2, and ethinyl estradiol inhibits this enzyme weakly. Rasagiline exposure may rise, increasing its adverse effects.
How serious is the interaction between Ethinyl estradiol-drospirenone and Rasagiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased rasagiline effects such as dizziness, hypotension and dyskinesia, and keep the dose at 0.5 mg daily if CYP1A2 inhibition is clinically relevant.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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